ࡱ> /-0  bjbjUU 4??   aaaaauuuu ufh(        pN a aa aa  I` u.60f,IaI  f  ': RCPsych Psychopharmacology Committee recommendations to be discussed for Choosing Wisely. 16 October 2015. Do not use valproate for any psychiatric illness in women of child-bearing potential unless other treatments are ineffective or not tolerated. (see HYPERLINK "https://www.gov.uk/drug-safety-update/medicines-related-to-valproate-risk-of-abnormal-pregnancy-outcomes"https://www.gov.uk/drug-safety-update/medicines-related-to-valproate-risk-of-abnormal-pregnancy-outcomes). Do not routinely initiate lithium therapy without establishing a process for monitoring adherence, physical health and plasma levels. (HYPERLINK "https://www.nice.org.uk/guidance/cg185"https://www.nice.org.uk/guidance/cg185). Do not prescribe paroxetine for the treatment of depression in children and adolescents. (BMJ. 2015 Sep 16;351). Do not prescribe stimulant medication for the treatment of ADHD in pre-school children. (i.e. under age 5: see https://www.nice.org.uk/guidance/cg72). Do not use dosulepin as a first-line treatment for depression.(Used because sedative, but relatively toxic in overdose, see, for example, Buckley & McManus. Can the fatal toxicity of antidepressant drugs be predicted with pharmacological and toxicological data? Drug Safety 1998;18:369-81). [\mn  x y l n p q  ( Ŷœ}}ňqeYhi>h+5OJQJhi>h%45OJQJhi>ha(5OJQJhi>h!"OJQJhi>h$:OJQJhi>h^OJQJhi>h$:0JOJQJhi>hZOJQJjhi>hZOJQJUhi>hOJQJhi>h$:5OJQJhi>h%4OJQJhi>h^5OJQJhi>h5OJQJ!\m D E F   $ ^ a$gddL$a$gdgdD]@$a$gddL $ ^ a$gdmV $ & Fa$gd9$ $h^ha$gddL $ & Fa$gddL$a$gddL( , C D E F G q  ! "     ƺїƺрuhi>hD]@OJQJhi>h(5OJQJhi>hm5OJQJhi>hoOJQJhi>hmV5OJQJhi>h5OJQJhi>hXQt5OJQJhi>h$:OJQJhi>hOJQJhi>h9$OJQJhi>hkN5OJQJhi>h5OJQJ21h:pZ. A!"#$% j 666666666vvvvvvvvv666666>6666666666666666666666666666666666666666666666666hH6666666666666666666666666666666666666666666666666666666666666666662 0@P`p2( 0@P`p 0@P`p 0@P`p 0@P`p 0@P`p 0@P`p8XV~ OJPJQJ_HmH nH sH tH J`J ZNormal dCJ_HaJmH sH tH DA`D Default Paragraph FontRiR 0 Table Normal4 l4a (k ( 0No List 6U@6 Q0 Hyperlink >*B*ph@@@  List Paragraph ^m$PK![Content_Types].xmlj0Eжr(΢Iw},-j4 wP-t#bΙ{UTU^hd}㨫)*1P' ^W0)T9<l#$yi};~@(Hu* Dנz/0ǰ $ X3aZ,D0j~3߶b~i>3\`?/[G\!-Rk.sԻ..a濭?PK!֧6 _rels/.relsj0 }Q%v/C/}(h"O = C?hv=Ʌ%[xp{۵_Pѣ<1H0ORBdJE4b$q_6LR7`0̞O,En7Lib/SeеPK!kytheme/theme/themeManager.xml M @}w7c(EbˮCAǠҟ7՛K Y, e.|,H,lxɴIsQ}#Ր ֵ+!,^$j=GW)E+& 8PK!0C)theme/theme/theme1.xmlYOo6w toc'vuر-MniP@I}úama[إ4:lЯGRX^6؊>$ !)O^rC$y@/yH*񄴽)޵߻UDb`}"qۋJחX^)I`nEp)liV[]1M<OP6r=zgbIguSebORD۫qu gZo~ٺlAplxpT0+[}`jzAV2Fi@qv֬5\|ʜ̭NleXdsjcs7f W+Ն7`g ȘJj|h(KD- dXiJ؇(x$( :;˹! I_TS 1?E??ZBΪmU/?~xY'y5g&΋/ɋ>GMGeD3Vq%'#q$8K)fw9:ĵ x}rxwr:\TZaG*y8IjbRc|XŻǿI u3KGnD1NIBs RuK>V.EL+M2#'fi ~V vl{u8zH *:(W☕ ~JTe\O*tHGHY}KNP*ݾ˦TѼ9/#A7qZ$*c?qUnwN%Oi4 =3N)cbJ uV4(Tn 7_?m-ٛ{UBwznʜ"Z xJZp; {/<P;,)''KQk5qpN8KGbe Sd̛\17 pa>SR! 3K4'+rzQ TTIIvt]Kc⫲K#v5+|D~O@%\w_nN[L9KqgVhn R!y+Un;*&/HrT >>\ t=.Tġ S; Z~!P9giCڧ!# B,;X=ۻ,I2UWV9$lk=Aj;{AP79|s*Y;̠[MCۿhf]o{oY=1kyVV5E8Vk+֜\80X4D)!!?*|fv u"xA@T_q64)kڬuV7 t '%;i9s9x,ڎ-45xd8?ǘd/Y|t &LILJ`& -Gt/PK! ѐ'theme/theme/_rels/themeManager.xml.relsM 0wooӺ&݈Э5 6?$Q ,.aic21h:qm@RN;d`o7gK(M&$R(.1r'JЊT8V"AȻHu}|$b{P8g/]QAsم(#L[PK-![Content_Types].xmlPK-!֧6 +_rels/.relsPK-!kytheme/theme/themeManager.xmlPK-!0C)theme/theme/theme1.xmlPK-! ѐ' theme/theme/_rels/themeManager.xml.relsPK] (   xp XXL# AA@0(  B S  ?_GoBack   =A 333} W  \^ `\o(.^`.pL^p`L.@ ^@ `.^`.L^`L.^`.^`.PL^P`L.} W        %mE5 !" 3%4(5$:D]@YIW(JkN{PmVXQtJz~Q9$O:Ca(+i>$^4AdLZozL  @ @UnknownG*Ax Times New Roman5Symbol3. *Cx Arial7. [ @Verdana7.@CalibriA$BCambria Math"qh::K K )$20  :HX  $PA2!xx Young, AllanKittiK Oh+'0  px  Young, AllanNormalKittiK3Microsoft Office Word@F#@ @ K՜.+,D՜.+,< hp  IoP King's College    Title 8@ _PID_HLINKSA (k'https://www.nice.org.uk/guidance/cg185Bihttps://www.gov.uk/drug-safety-update/medicines-related-to-valproate-risk-of-abnormal-pregnancy-outcomes  !#$%&'(),Root Entry F .1Table WordDocument4SummaryInformation(DocumentSummaryInformation8"CompObjy  F'Microsoft Office Word 97-2003 Document MSWordDocWord.Document.89qRoot Entry F` ) .1Table WordDocument4SummaryInformation(  !92345678՜.+,D՜.+,< hp  IoP King's College    Title 8@ _PID_HLINKSA (k'https://www.nice.org.uk/guidance/cg185Bihttps://www.gov.uk/drug-safety-update/medicines-related-to-valproate-risk-of-abnormal-pregnancy-outcomesDocumentSummaryInformation81CompObjy